José María Gutiérrez Selected Research

Enzymes

7/2021	Basement membrane degradation and inflammation play a role in the pulmonary hemorrhage induced by a P-III snake venom metalloproteinase.
4/2018	Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: Functional profiles of hemolytic and non-hemolytic isoforms.
1/2018	The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.
4/2015	Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.
11/2014	Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: identification of directly hemolytic phospholipases A2.
1/2014	Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?
2/2013	Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins.
2/2012	Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: toxicological and taxonomical insights.
12/2009	Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.
10/2003	Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.

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José María Gutiérrez Research Topics

Disease

73	Snake Bites (Snake Bite) 07/2022 - 06/2002
39	Hemorrhage 07/2021 - 03/2002
24	Edema (Dropsy) 07/2021 - 04/2002
22	Myotoxicity 03/2022 - 03/2002
17	Bites and Stings (Sting) 10/2021 - 01/2003
16	Necrosis 03/2021 - 06/2002
6	Thrombocytopenia (Thrombopenia) 07/2022 - 10/2003
6	Wounds and Injuries (Trauma) 10/2020 - 11/2009
5	Inflammation (Inflammations) 07/2021 - 01/2013
4	Pain (Aches) 11/2018 - 08/2002
4	Hemolysis 04/2018 - 03/2007
3	COVID-19 10/2021 - 01/2021
3	Thrombosis (Thrombus) 03/2013 - 10/2003
2	Disseminated Intravascular Coagulation 07/2022 - 10/2017
2	Infections 11/2020 - 01/2018
2	Shock 10/2020 - 12/2009
2	Blister (Bulla) 01/2019 - 10/2008
2	Hyperalgesia 09/2018 - 01/2017
2	Hypovolemia 01/2015 - 12/2009
2	Ischemia 12/2009 - 08/2002
2	Rupture 01/2006 - 02/2005
1	Acute Lung Injury 07/2021
1	Neglected Diseases 01/2020
1	Hemothorax 01/2019
1	Foot-and-Mouth Disease 01/2019
1	Atrophy 01/2018
1	Hypoxia (Hypoxemia) 01/2018

Drug/Important Bio-Agent (IBA)

75	VenomsIBA 07/2022 - 03/2002
63	Antivenins (Antivenoms)IBA 10/2021 - 06/2002
27	Snake Venoms (Snake Venom)IBA 07/2021 - 11/2003
23	Metalloproteases (Metalloproteinases)IBA 07/2021 - 10/2003
11	Proteins (Proteins, Gene)FDA Link 10/2021 - 06/2002
11	Immunoglobulin G (IgG)IBA 08/2021 - 06/2002
10	EnzymesIBA 07/2021 - 10/2003
9	Phospholipases A2 (Phospholipase A2)IBA 11/2020 - 12/2003
8	Phospholipases (Phospholipase)IBA 01/2018 - 04/2005
8	CoagulantsIBA 06/2017 - 09/2003
6	AntibodiesIBA 01/2021 - 02/2005
5	Peptide Hydrolases (Proteases)FDA Link 08/2021 - 11/2003
5	batimastat (BB 94)IBA 06/2017 - 04/2002
4	Collagen Type IV (Type IV Collagen)IBA 03/2021 - 10/2008
4	Laminin (Merosin)IBA 03/2021 - 10/2008
3	Creatine Kinase (Creatine Phosphokinase)IBA 03/2022 - 01/2008
3	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 11/2008
3	AnticoagulantsIBA 04/2018 - 08/2016
3	Interleukin-6 (Interleukin 6)IBA 01/2017 - 07/2004
3	Extracellular Matrix ProteinsIBA 12/2014 - 11/2009
3	estropipate (Ogen)FDA LinkGeneric 03/2013 - 07/2005
3	octanoic acid (caprylic acid)IBA 02/2012 - 12/2006
2	Indomethacin (Indometacin)FDA LinkGeneric 07/2021 - 01/2017
2	Complement System Proteins (Complement)IBA 01/2021 - 06/2002
2	varespladib methylIBA 11/2020 - 01/2018
2	varespladibIBA 11/2020 - 01/2019
2	Third Generation CephalosporinsIBA 01/2020 - 01/2018
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 01/2020
2	AntidotesIBA 01/2019 - 01/2010
2	Three Finger ToxinsIBA 01/2018 - 10/2014
2	Serine Proteases (Serine Protease)IBA 06/2016 - 03/2013
2	Pharmaceutical PreparationsIBA 01/2016 - 12/2008
2	Fibronectins (Fibronectin)IBA 12/2014 - 11/2009
2	Metallothionein 3IBA 01/2014 - 04/2002
2	ZincIBA 07/2012 - 07/2009
2	Prothrombin (Factor II)IBA 04/2012 - 10/2003
2	Phospholipases AIBA 02/2012 - 03/2010
2	Fibrinogen (Factor I)FDA Link 02/2012 - 12/2006
2	Hemostatics (Antihemorrhagics)IBA 01/2012 - 12/2009
2	NeurotoxinsIBA 12/2011 - 08/2010
2	CrotoxinIBA 12/2011 - 01/2008
2	Saline SolutionIBA 01/2006 - 06/2002
2	Bothrops jararaca VenomIBA 07/2005 - 11/2003
2	PeptidomimeticsIBA 03/2004 - 04/2002
1	Pentoxifylline (Trental)FDA LinkGeneric 07/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020
1	AntigensIBA 10/2020
1	ProteomeIBA 01/2019
1	Tramadol (K315)FDA LinkGeneric 11/2018
1	Analgesics (Analgesic Drugs)IBA 11/2018
1	Morphine (MS Contin)FDA LinkGeneric 11/2018
1	phytobacteriomycin (PBM)IBA 09/2018
1	Protein Isoforms (Isoforms)IBA 04/2018
1	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 01/2018
1	Amoxicillin (Wymox)FDA LinkGeneric 01/2018
1	arachidonyltrifluoromethaneIBA 01/2017
1	Endothelin Receptors (Endothelin Receptor)IBA 01/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017
1	palmitoyl trifluoromethyl ketoneIBA 01/2017
1	Cyclooxygenase InhibitorsIBA 01/2017
1	Lipoxygenase InhibitorsIBA 01/2017
1	ilomastatIBA 01/2017
1	Celecoxib (Celebrex)FDA Link 01/2017
1	Serotonin AntagonistsIBA 01/2017

Therapy/Procedure

18	Therapeutics 10/2021 - 01/2003
6	Intravenous Injections 07/2021 - 06/2002
4	Intravenous Administration 07/2005 - 10/2003
1	First Aid (Aids, First) 01/2021
1	Immunotherapy 01/2021
1	Punctures 01/2019
1	Thoracostomy 01/2019
1	Low-Level Light Therapy (LLLT) 09/2018
1	Complementary Therapies (Alternative Medicine) 01/2018